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DoseMeRX - Real-time precision dosing

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DoseMe

The world's first easy-to-use precision dosing software designed for clinicians to improve dosing accuracy and patient outcomes by predicting the optimal individualized dose of medications to safely reach therapeutic concentrations quicker.

Using SMART® and FHIR® technologies, DoseMeRx extracts patient characteristics, dose administered, renal function and previous response to therapy. Leveraging clinically validated pharmacokinetic drug models, DoseMeRx models how each patient is responding to therapy from as-little-as one assay, taking into account individual variability in genes, environment and lifestyle to accurately calculate an individualized dose to reach a therapeutic target.

Reduce adverse events and improve patient outcomes, while decreasing time spent on dose adjustments and the number of assays required to optimize a patient's dose for numerous antibiotics including vancomycin and the aminoglycosides, as well as immunosuppressants, chemotherapeutic agents, and many more.

Use Cases

  • An adult infectious disease pharmacist adjusts a vancomycin dose for a MRSA patient, aiming for a trough concentration of 10-15mcg/mL, although the only assay available was taken three hours earlier than intended, he uses DoseMeRx to calculate the trough level reached and a safe therapeutic dose without an unnecessary and expensive additional assay.
  • A clinical pharmacist adjusts vancomycin dosing for an 11-day old 3.6kg neonate admitted to NICU with sepsis - DoseMeRx automatically accounts for renal impairment and recommends lowering the dose by 20mg in comparison to guidelines, placing the patient in the safe and therapeutic range to avoid the risk of acute kidney injury.
  • A pediatric infectious disease pharmacist receives only the first post-infusion blood test for a 16-year-old cystic fibrosis patient on IV tobramycin and by using DoseMeRx, an accurate AUC is calculated with only one assay, where without DoseMeRx, no calculation of pharmacokinetics would have been possible.
  • A physician treating lupus-associated glomerulonephritis with cyclosporine intentionally introduces diltiazem concomitantly to increase blood levels of cyclosporine - using DoseMeRx she calculates a dose that quantitatively measures the patient’s drug-drug interaction size, accurately placing the patient into the therapeutic range.

Supported Devices

  • Desktop
  • Tablet

Version Details

DoseMeRx Release Version 1.00 and above

Requires: Cerner Release Version 2015.01 and above

Key Features

Real-time Visualization of PK-PD

Therapeutic drug monitoring no longer needs to be laborious or trial and error. Quickly and accurately calculate an individualized dose modelled on your patient’s PK-PD from as-little-as one assay to reach your therapeutic target quicker.

Compare Individualized, Guideline and Label Dose Recommendations

Quickly and easily calculate an individualized dose to a range of therapeutic targets, including AUC, Peak-Trough and Time in Range and compare this to your hospital guidelines and label recommendations to optimize decision making.

Customize Dose and Simulate Outcomes

Clinicians can override the individualized, guideline and label dose options to simulate other dose regimens. DoseMeRx then calculates the most likely outcome of administrating that dose enabling trial and error before administering this to your patient.

Simple to Calculate First Dose

Calculate first dose using your hospital guidelines or from a peer-reviewed source, automatically incorporating not only the patient’s physical characteristics such as weight, but also any relevant pathology results such as renal and liver function – all within seconds to help achieve a therapeutic concentration more quickly.


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