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OpiSafe, Powered by RxAdvisor

OpiSafe is a medication monitoring platform that prevents prescription drug abuse without causing harm to patients. OpiSafe allows providers to monitor risks of misuse related to opioids and other medications.

OpiSafe powers opioid stewardship initiatives and sets organizations up with tools for physicians to prescribe safely and achieve optimal outcomes not only for opioids, but also for behavioral health medications. OpiSafe provides clinicians a comprehensive view and quickly identify risks associated with prescription medications including opioids. The platform increases prescriber compliance with regulations related to prescription monitoring laws and improves outcomes such as reduction in opioid prescriptions, reduction in MME, targeted naloxone distribution and improved referral to treatment.

Simply put - OpiSafe is “More Powerful and Less Costly” than any other medication monitoring alternative.

Use Cases

  • As a clinical decision support platform, OpiSafe presents the state PMP report in a manner consistent with state requirements and aligns clinical insights from the EHR within a single dashboard. Depending on state prescription monitoring laws, users may include prescribers and their delegates.

  • Efficiently detect opioid or behavioral health medication misuse or risk of overdose
    Clinicians can easily access prescription drug monitoring (PMP) fill history and toxicology results right in the Cerner workflow while evaluating the patient’s information. Key insights are presented to the clinician to make it faster to analyze the PMP fill history: Dosing / MME trends, Multiple Provider Episode metrics, instances of Co-prescribing of Opioids and Benzodiazepines.

  • One-click access to best practice guidelines for optimal opioid management
    Easy to use clinical guidelines for pain and addiction management to quickly access information such as: MAT induction protocols, American College of Emergency Medicine guidelines for Alternatives to Opioids (ALTO) for acute pain, and CDC guidelines for chronic pain management.

  • Locate and refer to treatment based on patient preferences to reduce ED readmissions and improve outcomes
    When clinicians determine follow-up Medication Assisted Treatment is beneficial for a patient, clinicians can find treatment provider options for the patient based on location, types of services offered and insurance coverage to help connect patients when they are most receptive to the follow-up care.

  • Access and evaluate performance metrics
    Analytics to monitor regulatory compliance and outcomes, identify how the tool is being used by clinicians, and identify opportunities for increasing uptake, supporting quality improvement initiatives, incentive payments, and making deployment enhancements

Available in These Countries

  • United States

Supported Devices

  • Desktop

Version Details


Key Features

Prescription Optimization

Prescription Optimization means getting the best outcome for every prescription written. OpiSafe curates available pieces of information needed for clinicians to make the best clinical decision, monitor outcomes, view laboratory results and consider patient responses to support future prescribing interventions.

Prevent, Detect and Treat Improper Use of Prescription Medications

OpiSafe, powered by RxAdvisor, pulls from multiple data streams including the PMP, toxicology reports, and other patient data in the EHR or outside the EHR and interprets it in seconds. In just one click, OpiSafe seamlessly integrates into the provider EHR workflow, making it easy to ensure your providers comply with state laws and best practice guidelines.

Easy Reference to Clinical Guidelines

Organizations using the OpiSafe application experienced a 4-fold increase in CDC chronic pain guideline adherence.

Bridge to Treatment

Allows clinicians to locate medication-assisted treatment options to help connect individuals to treatment as fast as possible.

Validated Clinical Study

Journal of Addiction Medicine publication demonstrating the results of the OpiSafe application for clinicians.