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Elsevier’s ClinicalKey

Elsevier’s ClinicalKey is a clinical decision support tool that delivers quick, credible answers at the point of care alongside trusted, comprehensive medical evidence to support practitioners’ clinical information needs.

With ClinicalKey, best practices, treatment information, and medication details are all available at the point of care, allowing clinicians to make recommendations based on the latest research. ClinicalKey also offers them the tools they need to dig deeper and explore unusual, rare or complex conditions. All of this medical knowledge is continuously updated and approved by experienced, board-certified editors. With access to both deep references and disease overviews, the entire care team can enhance patient care based on current evidence.

Use Cases

  • A patient arrives in the ED showing signs of atrial fibrillation. Her patient chart reveals several comorbid conditions. This makes the care decision more complex for the clinician, who needs to get the A fib under rate control. Accessing ClinicalKey, she quickly finds a Clinical Overview for A fib that includes an algorithm on rate control, which indicates a beta blocker is best for the patient. She then uses the suggested calculator which confirms the need to anticoagulate the patient. The clinician reviews the drug monograph for Apixaban to verify dosage – and a recent JACC article supports her decision. Using a combination of point-of-care and deep reference content, the physician is able to make the most appropriate care decisions in the moment.

  • A patient arrives in the ED after being administered Narcan by paramedics for a Vicodin overdose. Now awake and alert, she informs the physician when and how many pills she had taken. Ingestion happened 6 hours earlier – so he knows that every moment counts. He performs a search for “Tylenol overdose” in ClinicalKey and clicks on the Clinical Overview. A list of urgent actions and drug treatment dosage table appear on the same easy-to-read screen. The physician scans both to determine his next course of action. Jumping directly to the right information saved him valuable time.

  • A nurse practitioner in a cardiology specialty practice is seeing a 60-year-old female patient who was recently diagnosed with coronary artery disease. She is not tolerant of statin therapy because of muscle aches. Now off cholesterol-lowering medications, her LDL cholesterol is 150mg/dl. The nurse practitioner is considering use of Bempedoic Acid, a non-statin lipid-lowering agent. She searches “bempedoic acid” in ClinicalKey and chooses the first search result, which is the Bempedoic Acid Drug Monograph, where she quickly navigates to the Indications & Dosage section. After reviewing, she goes back to the search results page and selects the result that is a full-text article titled 2022 ACC Expert Consensus… which contains a treatment algorithm, allowing her to effectively prescribe the right therapy for the patient.

  • A urologist is seeing a 54-year-old male patient in follow-up for benign prostatic hypertrophy (BPH). The patient notes that he stopped taking tamsulosin (trade name Flomax) after two months because of headaches. He’s been trying to manage his symptoms by limiting alcohol and caffeine, but he would like another medication trial. The urologist searched “alpha blockers” within drug class overviews in ClinicalKey. He was able to review the Adverse Reactions/Side Effects Table to find a medication with a lower reported incidence of headache.

ClinicalKey is continuously updated - 2023 key updates:

  • Drug information updates:
    • Drug Monographs and Drug Class Overviews added to ClinicalKey for seamless access at the point of care

    • Pregnancy and Lactation content added to Drug Monographs

    • Improved drug monograph navigation to help clinicians find quick answers at the point of care

  • Clinical Topics:
    • 120 new Clinical Overviews to help clinicians find quick answers at the point of care

    • Deep Dive for specialties and deeper questions

    • Books: 29 new; 57 updated

    • Journals: 25 new

Available in These Countries

  • Cerner integration supported in the United States and Canada.

Supported Devices

  • Desktop
  • Tablet

Version Details

Compatible with Cerner Powerchart

Key Features


Quickly surface the information you need at the point of care

Clinical overviews are easy-to-scan, evidence-based medical synopses linked to full-text references on a wide range of specialties, available in seconds through intuitive, categorized search results, saving clinicians critical time.


Instantly assess drug considerations

With ClinicalKey’s built-in pharmacology insights, clinicians can fully assess the various factors involved in effective patient care according to the latest drug information. This means they’ll be better positioned make treatment recommendations with greater precision.


Interactive calculators to support clinical decisions

Over 600 Drug, Clinical Criteria, Decision Tree, Medical, and Unit Conversion Calculators are available to aid clinicians in assessment and decision-making.


Build foundational knowledge and evolve your practice

By tapping into the collection of world-class, full-text reference materials spanning 30+ specialties in ClinicalKey, providers can broaden their expertise and develop a deeper understanding of the clinical subjects most relevant to their practice. With access to the latest research and findings from full-text journals, including new articles awaiting publication, clinicians can stay aligned with best practices and have the validation they need to pursue new treatments as research continues to evolve.


Earn CME and fulfill MOC requirements

Physicians can earn 0.5 AMA PRA Category 1 Credit™ for the clinical searches they conduct daily. Additionally, physicians in the U.S. can submit the CME credit they earn on ClinicalKey for Maintenance of Certification credit with the American Board of Internal Medicine.